Spanish National Research Council
Inst. Quimica-Fisica "Rocasolano". CSIC
28006 Madrid MadridSpain
Structural Biology/ X-ray Crystallography / Protein Engineering / Bioinformatics
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The research carried out in the group employs a multidisciplinary approach with X-ray crystallography, Protein Engineering and Bioinformatics tools aiming to provide knowledge of the three-dimenture of proteins and analysis of their various interactions and ligand complexes as a prerequisite for an in-depth understanding of any biological process. The research interests in our group encompass studies in the mechanisms of virulence and pathogenesis and the means of circumvent them. We focus on the structural biology of the pneumococcal surface proteins involved in key functions, such as binding of the pathogen to host cellular receptors or the remodeling of the peptidoglycan framework, which represent important mechanisms in the process of disease. The mechanisms of action of endolysins (phage-encoded enzymes that break down bacterial peptidoglycan) are also studied as potential pharmaceutical agents (enzybiotics).
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