Dr. Rajesh Mondal

Researcher

Address: 

Dr. Rajesh  Mondal

Molecular Pathogenesis Lab, Department of Microbiology

Dr. Hari Singh Gour Central University

Sagar-  M.P.  470003

India

Phone number: 

+91 9669292564

Any further information you consider relevant: 

As a postdoctoral fellow at Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville (U.S.A.) I had worked on eukaryotic host cell receptors for E. coli common pilus (ECP), a fibrillar structural protein with a potential role in host epithelial cell colonization and may represent a mechanism of adherence of both pathogenic and commensal E.coli. We observed that purified ECP fibers can bind directly to the cell monolayers at the significant level but the cell surface receptors responsible for this binding are still unknown. Since, ECP is a novel adhesion of E. coli (EPEC and EHEC) and acts in concert with the bundle-forming pilus in the formation and stability of the localized microcolonies formed on cultured epithelial cells, we want to understand the mechanism of ECP-mediated adherence and also, how ECP is regulated and assembled. We got some excellent data from this project and submitted an article Jourinal of Bacteriology. Additionally, I was also involved in another project on Type-2 protein secretion system of Pseudomonas aeruginosa. Diverse group of virulent strains of P. aeruginosa, grown under standard and different growth conditions was studied for toxin production and effect on mice (especially for Type-2 protein secretion system). With the help of Two Dimensional Fluorescence Difference Gel Electrophoresis (2-D DIGE) coupled with Mass Spectrometry (MALDI-QTOF), we were able to identify and characterize some type 2 secretary proteins responsible for the early death of mice. I am open to collaborate with the scientist working on Pseudomonas, E coli & Klebsiella spp & also the gram positive ones with Staphylococcus.

Your research topics: 

antimicrobial resistance

diagnostic

interactions host-pathogen

pathogenicity

prevention

treatment

Organism studied by your group: 

Bacteria

Special methods/technologies: 

Genetic

Imaging

Molecular Biology

Screening