Instituto de Medicina Molecular
Av. Prof. Egas Moniz, Av. Prof. Egas Moniz
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Spectroscopic techniques, biophysics, microbiology.
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Biochemical and biophysical processes occurring at the level of the membranes of human cells, as well as of their viral and bacterial pathogens. Pre-clinical evaluation of the membrane activity and mechanism of action at the molecular level of antimicrobial peptides (AMPs). Application of nanotechnology to study morphology and topography os cell surface as well as protein-ligand interaction (cell-cell), binding force and rupture force.
Any further information you consider relevant:
Ribeiro, Felício MR, Vilas Boas E, Gonçalves S, Costa F, Samy RP, Santos NC; Franco OL. New frontiers for antibiofilm drug development. Accepted for publication in Pharmacology and Therapeutics in January 2016. Cardoso M, Ribeiro S, Nolasco D, Fuente-Núñez F, Felício M, Gonçalves S, Matos C, Liao L, Nuno Santos, Robert Hancook, Octavio Franco, and Ludovico MiglioloA polyalanine peptide derived from polar fish with anti-infectious activities. Accepted for publication in Scientific Reports in January 2016. Hollmann A, Gonçalves S, Augusto MT, Castanho MA, Lee B, Santos NC. Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture. Nanomedicine. 2015 Jul;11(5):1163-7. doi: 10.1016/j.nano.2015.02.014. Epub 2015 Mar 17. Viana JF, Carrijo J, Freitas CG, Paul A, Alcaraz J, Lacorte CC, Migliolo L, Andrade CA, Falcão R, Santos NC, Gonçalves S, Otero-González AJ, Khademhosseini A, Dias SC, Franco OL. Antifungal nanofibers made by controlled release of sea animal derived peptide. Nanoscale. 2015 Apr 14;7(14):6238-46. doi: 10.1039/c5nr00767d. Bravo-Ferrada BM, Gonçalves S, Semorile L, Santos NC, Tymczyszyn EE, Hollmann A. Study of surface damage on cell envelope assessed by AFM and flow cytometry of Lactobacillus plantarum exposed to ethanol and dehydration. J Appl Microbiol. 2015 Jun;118(6):1409-17. doi: 10.1111/jam.12796. Epub 2015 Mar 30. Silva PM, Gonçalves S, Santos NC. Defensins: antifungal lessons from eukaryotes. Front Microbiol. 2014 Mar 20;5:97. doi: 10.3389/fmicb.2014.00097. eCollection 2014. Review. Matos PM, Gonçalves S, Santos NC. Interaction of peptides with biomembranes assessed by potential-sensitive fluorescent probes. J Pept Sci. 2008 Apr;14(4):407-15. doi: 10.1002/psc.1005. Review. Gonçalves S, Abade J, Teixeira A, Santos NC. Lipid composition is a determinant for human defensin HNP1 selectivity. Biopolymers. 2012;98(4):313-21.
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